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KMID : 0364820120480010052
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Korean Journal of Microbiology
2012 Volume.48 No. 1 p.52 ~ p.56
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Antimicrobial Effect of Carvacrol against Cariogenic and Periodontopathic Bacteria
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Park Soon-Nang
Lee Dong-Kyun
Lim Yun-Kyong
Kim Hwa-Sook
Cho Eu-Gene
Kim Dong-Chun
Kim Sang-Gon
Kook Joong-Ki
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Abstract
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The aim of this study was to evaluate the antimicrobial effect of carvacrol against periodontopathic and cariogenic
bacteria and its cytotoxicity in human oral tissue cells. We tested their antibacterial properties against mutans
streptococci and five major periodontopathic bacterial species involved in periodontal disease. The antimicrobial
activity was evaluated by the minimal inhibitory concentration (MIC) and minimum bactericidal concentration
(MBC). The cell viability of carvacrol on normal human gingival fibroblast (NHGF) cells was tested by metyl
thiazolyl tetrazolium assay. The data showed that carvacrol had remarkable antimicrobial effect on tested bacteria
with a MIC and MBC values ranged from 16 to 128 μg/ml and from 32 to 128 μg/ml, respectively. In cell toxicity
studies, carvacrol had significantly decreased cell viability when NHGF cells were treated at 128 μg/ml. These
findings suggest that carvacrol has a strong antimicrobial activity against periodontopathic and cariogenic bacteria.
However, in order to use it as a component of gargling solution or toothpaste, its concentration should be below 64
μg/ml and other compounds having an antimicrobial activity against periodontopathic and cariogenic bacteria should
be used together.
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KEYWORD
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antimicrobial effect, carvacrol, mutans streptococci, periodontopathogens
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